Lijie Han

EDUCATION

Master's, General Surgery, Shanghai Jiaotong University School of Medicine (2022)

Bachelor's, Clinical Medicine, Wenzhou Medical University (2020)

SUMMARY

Han is interested in studying the clinical phenomenon and molecular biochemistry of pancreatic cancer, including the tumor metabolism and microenvironment of Pancreatic Ductal Adenocarcinoma (PDAC). In 2023, Han join the Krainer Lab, and is now interested in developing antisense oligonucleotide therapies based on PKM splicing to treat PDAC. Outside of the lab, he enjoy travelling, cooking and taking photographs.

PUBLICATIONS

Xue M, Zhu Y, Jiang Y, Han L, Shi M, Su R, Wang L, Xiong C, Wang C, Wang T, Deng S, Wu D, Cao Y, Dong L, Bai F, Zhao S, Deng X, Peng C, Li H, Chen J, Shen B, Jiang L, Chen H. Schwann cells regulate tumor cells and cancer-associated fibroblasts in the pancreatic ductal adenocarcinoma microenvironment. Nat Commun. 2023 Jul 31

Jiang Y, Han L, Yang J, Yang M, Zhang J, Xue M, Zhu Y, Xiong C, Shi M, Zhao S, Shen B, Xu Z, Jiang L, Chen H. Identification of a novel immune checkpoint molecule V-set immunoglobulin domain-containing 4 that leads to impaired immunity infiltration in pancreatic ductal adenocarcinoma. Cancer Immunol Immunother. 2023 Aug

Jiang Y, Han L, Xue M, Wang T, Zhu Y, Xiong C, Shi M, Li H, Hai W, Huo Y, Shen B, Jiang L, Chen H. Cystatin B increases autophagic flux by sustaining proteolytic activity of cathepsin B and fuels glycolysis in pancreatic cancer: CSTB orchestrates autophagy and glycolysis in PDAC. Clin Transl Med. 2022 Dec;12

Wang L , Han L , Tao Z , Zhu Z , Han L , Yang Z , Wang H , Dai D , Wu L , Yuan Z , Chen T . The curcumin derivative WZ35 activates ROS-dependent JNK to suppress hepatocellular carcinoma metastasis. Food Funct. 2018 May 23