Lucia Yang

EDUCATION

B.S. Neuroscience, UCLA, 2019 

SUMMARY

Lucia completed her B.S. in Neuroscience with a minor in Global Studies at UCLA. While there, she worked in the lab of Dr. X. William Yang and navigated the intersection of molecular biology and mouse genetics to study Huntington's disease. Her senior thesis described the chromatin landscape of Huntington's disease mouse models using Assay for Transposase-Accessible Chromatin sequence (ATAC-seq). In 2019, she joined Stony Brook University's MSTP and developed a strong clinical interest in oncology. In 2021, Lucia joined the Krainer Lab, and is now interested in developing antisense oligonucleotide therapies to treat diffuse midline gliomas. 

Outside of lab, she enjoys hiking, trivia, catching up on TV shows and movies, and annoying her cat, Minerva. 

PUBLICATIONS

Zhang Q, Yang L, Liu YH, Wilkinson JE, Krainer AR. Antisense oligonucleotide therapy for H3.3K27M diffuse midline glioma. Sci Transl Med. 2023;15(691):eadd8280. doi:10.1126/scitranslmed.add8280.

Kim YJ, Nomakuchi T, Papaleonidopoulou F, Yang L, Zhang Q, Krainer AR. Gene-specific nonsense-mediated mRNA decay targeting for cystic fibrosis therapy. Nat Commun. 2022 May 27;13(1):2978. doi: 10.1038/s41467-022-30668-y. 

Gu X, Richman J, Langfelder P, Wang N, Zhang S, Bañez-Coronel M, Wang HB, Yang L, Ramanathan L, Deng L, Park CS, Choi CR, Cantle JP, Gao F, Gray M, Coppola G, Bates GP, Ranum LPW, Horvath S, Colwell CS, Yang XW. Uninterrupted CAG repeat drives striatum-selective transcriptionopathy and nuclear pathogenesis in human Huntingtin BAC mice. Neuron. 2022 Apr 6;110(7):1173-1192.e7. doi: 10.1016/j.neuron.2022.01.006. 

Kim YJ, Sivetz N, Layne J, Voss DM, Yang L, Zhang Q, Krainer AR. Exon-skipping antisense oligonucleotides for cystic fibrosis therapy. Proc Natl Acad Sci U S A. 2022 Jan 18;119(3):e2114858118. doi: 10.1073/pnas.2114858118.